Cell biology and application
in cancer research
Sinh học tế bào
TS. Nguyễn Thụy Vy
1Sinh học tế o – CNSH
Figure 20-11 Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 2
Clonal evolution of
cancer epithelial cells
Figure 20-17 Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 3
Cancer Cells have an Altered Sugar
Metabolism
Sinh học tế o – CNSH 4
Figure 20-39b Molecular Biology of the Cell (© Garland Science 2008)
Disruptions in a handful of Key Pathways
Are Common to Many
Sinh học tế o – CNSH 5
Figure 20-40 Molecular Biology of the Cell (© Garland Science 2008)
Mutations in the p53 Pathway Enable Cancer
Cells to Survive and Proliferate Despite Stress
and DNA Damage
Sinh học tế o – CNSH 6
Figure 20-14 Molecular Biology of the Cell (© Garland Science 2008)
Cancer Cells have an Abnormal
Ability to Survive Stress and DNA
Sinh học tế o – CNSH 7
Figure 20-42 Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 8
Figure 20-43 Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 9
The tumor microenvironment influences
cancer development
Sinh học tế o – CNSH 10
A Small Population of Cancer Stem Cells
May Maintain Many Tumors
Sinh học tế o – CNSH 11
Figure 20-44 Molecular Biology of the Cell (© Garland Science 2008)
The Changes in Tumor Cells That Lead to
Metastasis Are Still Largely a Mystery
Sinh học tế o – CNSH 12
Sinh học tế o – CNSH 13
CANCER PREVENTION AND TREATMENT:
PRESENT AND FUTURE
Figure 20-20b Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 14
Table 20-1 Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 15
Traditional Therapies Exploit the Genetic
Instability and Loss of Cell-Cycle
Checkpoint Responses in Cancer Cells
Sinh học tế o – CNSH 16
Antibody-drug Conjugates
Sinh học tế o – CNSH 17
Brentuximab vedotin
Figure 20-51 Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 18
Figure 20-52a Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 19
Figure 20-52c Molecular Biology of the Cell (© Garland Science 2008)
Sinh học tế o – CNSH 20

Preview text:

Cell biology and application in cancer research Sinh học tế bào TS. Nguyễn Thụy Vy Sinh học tế bào – CNSH 1 Clonal evolution of cancer epithelial cells
Figure 20-11 Molecular Biology of the Cell (© Garland Science 2008) Sinh học tế bào – CNSH 2 Sinh học tế bào – CNSH 3
Figure 20-17 Molecular Biology of the Cell (© Garland Science 2008)
Cancer Cells have an Altered Sugar Metabolism Sinh học tế bào – CNSH 4
Disruptions in a handful of Key Pathways Are Common to Many Sinh học tế bào – CNSH 5
Figure 20-39b Molecular Biology of the Cell (© Garland Science 2008)
Mutations in the p53 Pathway Enable Cancer
Cells to Survive and Proliferate Despite Stress and DNA Damage Sinh học tế bào – CNSH 6
Figure 20-40 Molecular Biology of the Cell (© Garland Science 2008) Cancer Cells have an Abnormal
Ability to Survive Stress and DNA Sinh học tế bào – CNSH 7
Figure 20-14 Molecular Biology of the Cell (© Garland Science 2008) Sinh học tế bào – CNSH 8
Figure 20-42 Molecular Biology of the Cell (© Garland Science 2008) Sinh học tế bào – CNSH 9
Figure 20-43 Molecular Biology of the Cell (© Garland Science 2008)
The tumor microenvironment influences cancer development Sinh học tế bào – CNSH 10
A Small Population of Cancer Stem Cells May Maintain Many Tumors Sinh học tế bào – CNSH 11
The Changes in Tumor Cells That Lead to
Metastasis Are Still Largely a Mystery Sinh học tế bào – CNSH 12
Figure 20-44 Molecular Biology of the Cell (© Garland Science 2008)
CANCER PREVENTION AND TREATMENT: PRESENT AND FUTURE Sinh học tế bào – CNSH 13 Sinh học tế bào – CNSH 14
Figure 20-20b Molecular Biology of the Cell (© Garland Science 2008) Sinh học tế bào – CNSH 15
Table 20-1 Molecular Biology of the Cell (© Garland Science 2008)
Traditional Therapies Exploit the Genetic
Instability and Loss of Cell-Cycle
Checkpoint Responses in Cancer Cells Sinh học tế bào – CNSH 16 Antibody-drug Conjugates Brentuximab vedotin Sinh học tế bào – CNSH 17 Sinh học tế bào – CNSH 18
Figure 20-51 Molecular Biology of the Cell (© Garland Science 2008) Sinh học tế bào – CNSH 19
Figure 20-52a Molecular Biology of the Cell (© Garland Science 2008) Sinh học tế bào – CNSH 20
Figure 20-52c Molecular Biology of the Cell (© Garland Science 2008)